Thursday, 14th March, 2024
12:00 – 12:45 Poster Set-up
12:45 – 13:00 Welcome and Organizational Issues
13:00 – 14:30 Session 1: Cardio-immunology
Chairs: Blanche Schroen (Maastricht, NL), Sophie van Linthout (Berlin, DE)
Presentations:
- Speaker 1: Sophie van Linthout (Berlin, DE); New targets of treatment: Immune mechanisms
- Speaker 2: Saskia de Jager (Utrecht, NL); Non-classical monocytes are associated with clinical markers of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction
- Speaker 3: Gustavo Ramos (Würzburg, DE); Tracking heart-specific T cell responses in myocardial diseases – from mice to humans
- Speaker 4: Wouter Meijers (Rotterdam, NL); Immune checkpoints in Cardiac Injury
14:30 – 16:00 Poster Session I and coffee
16:00 – 16:30 Special clinical translational lecture: Hans Nienhuis (Groningen, NL), Cardiac amyloidosis
16:30 – 18:00 Session 2: Metabolism and mitochondria
Sponsored by Double Dose
Chairs: Christoph Maack (Würzburg, DE), Martijn Hoes (Maastricht, NL)
Presentations:
- Speaker 1: Laura Meems (Groningen, NL); Cardiometabolic syndrome and Heart Failure: mechanistic insights and management strategies
- Speaker 2: Pieterjan Dierickx (Bad Nauheim, DE); Circadian Regulation of Cardiometabolism
- Speaker 3: Daan Westenbrink; Effect of oral ketone supplementation on exercise performance and muscular energy balance in heart failure patients
- Speaker 4: Joost Luiken (Maastricht, NL); Activating v-ATPase ameliorates lipid-induced cardiomyopathy
20:00 Dinner at NOK Forum
Friday, 15th March, 2024
9:30 – 11:00 Session 3: Genetic predisposition and cardiomyopathies
- Chairs: Rudolf de Boer (Rotterdam, NL), Arne Hansen (Hamburg, DE)
Presentations:
- Speaker 1: Eva van Rooij (Utrecht, NL); New concepts to treat arrhythmogenic cardiomyopathy
- Speaker 2: Lukas Cyganek (Göttingen, DE); Testing of pharmacological and CRISPR-based therapies for LZTR1-associated Hypertrophic Cardiomyopathy
- Speaker 3: Jolanda van der Velden (Amsterdam, NL); Metabolic remodeling in hypertrophic cardiomyopathy – diverse cardiac phenotypes
- Speaker 4: Simon Lebek (Regensburg, DE); Gene Editing To Fight Cardiovascular Diseases
11:00 – 11:30 Coffee Break
11:30 – 13:00 Session 4: The single cell resolution revolution – Temporal and spatial omics
Chairs: Mirko Völkers (Heidelberg, DE), Marit Westerterp (Groningen, NL)
Presentations:
- Speaker 1: Lars Maegdefessel (Munich, DE); ‘Multi-omic profiling of atherosclerosis and mechanisms of plaque destabilization
- Speaker 2: Amanda Foks (Leiden, NL); Single cell profiling of age-associated immunity in atherosclerosis
- Speaker 3: Reinier Boon (Amsterdam, NL); cardiovascular aging
- Speaker 4: Daniela Panakova (Berlin, DE); Cellular drivers of heart regeneration
13:00 – 14:30 Poster Session II and Lunch
14:30 – 15:15 Keynote Lecture: Prof. dr. Manuel Mayr (Imperial College London); The Proteomic Landscape of Dilated Cardiomyopathy
This lecture is sponsored by the Dutch Heart Foundation
15:15 – 15:45 Coffee Break
15:45 – 17:15 Session 5: Young Investigator Award Session Judge
Chairs: Brenda Gerull (Würzburg, DE), Robert Passier (Enschede, NL)
Presentations:
- Speaker 1: Federico Bleckwedel; The Role of Cardiomyocyte-Derived EVs in Compensatory Hypertrophic Remodeling
- Speaker 2: Mariel Cano-Jorge; Effect of dynamic preload on human-engineered ventricles
- Speaker 3: Johanna Siegel; Antibody responses to myocardial antigens released in the context of a myocardial infarction
- Speaker 4: Michiel Blok; The right ventricular outflow tract displays a small L-type calcium current and transient amplitude due to a unique gene expression profile involving SYT1
18:30 Dinner at BOEL
Saturday, 16th March, 2024
9:00 – 10:30 Session 6: The heart rhythm’s riddles
Chairs: Bas Boukens (Maastricht, NL), Rupamanjari Majumder (Göttingen, DE)
Presentations:
- Speaker 1: Tim de Coster (Leiden, NL); Closed-loop control systems for cardiac rhythm regulation
- Speaker 2: Franziska Schneider-Warme (Freiburg, DE); Optogenetic investigation of myocytes and non-myocytes in cardiac remodeling
- Speaker 3: Harsha Devalla (Amsterdam, NL); Studying conduction dysfunction using hiPSC-derived cardiac assembloids
- Speaker 4: Justus Stenzig (Hamburg, DE); Using optogenetics and tissue engineering to dissect individual aspects of atrial fibrillation pathophysiology
10:30 – 11:00 Coffee Break
11:00 – 11:45 Lecture by Tenaya Therapeutics, Huanyu Zhou; Gene Editing of the R14del Mutation Rescues PLN-R14del-Associated Cardiomyopathy
11:45 – 12:30 Lunch Break
12:30 – 14:00 Session 7: Mechanisms of novel therapeutics
Chairs: Peter van der Meer (Groningen, NL), Streckfuss-Bömeke (Würzburg, NL)
Presentations:
- Speaker 1: Christian Kupatt (München, DE)
- Speaker 2: Gabriele Schiattarella (Berlin, DE); Metabolic Underpinnings in Obese Heart Failure with Preserved Ejection Fraction (HFpEF)
- Speaker 3: Laura Zelarayan (Göttingen, DE); CRISPRA & Gene Regulation in the Heart
- Speaker 4: Joost Sluijter (Utrecht, NL); Extracellular Vesicles as vehicles for reparative therapies
14:00 YIA Winner and Poster Prize Announcement
14.20 Announcement next year venue
14:30 Departure
Poster and YIA Judges:
Brenda Gerull (Würzburg, DE)
Robert Passier (Enschede, NL)
Larissa Fabritz (Hamburg, DE)
Toon van Veen (Utrecht, NL)
Jan Willem Buikema (Amsterdam, NL)
Anke Smits (Leiden, NL)
Daan Westenbrink (Groningen, NL)
Nils Bömer (Groningen, NL)
Marie-Jose Goumans (Leiden, NL)
