The DECISION trial is the first randomized clinical trial (RCT) with digoxin in HF patients with sinus rhythm in 25 years, and the first RCT ever in HF patients with AF. This trial was initiated in Groningen and will determine whether a low dose of digoxin, aiming for serum concentrations 0.5-0.9 ng/mL, is beneficial in a wide spectrum of patients with HF (LVEF <50%).
So far, 662 out of 982 patients have been included in 44 participating hospitals throughout the country.
End of inclusion is expected in the second half of 2023.
End of follow-up is expected halfway 2025!